Three Rivers College was founded April 5, 1966, when citizens of Butler, Carter, Ripley and Wayne counties located in southeast Missouri, voted into existence the Three Rivers Junior College District.

Since that time, the college has grown and prospered. Beginning in storefront facilities in downtown Poplar Bluff, Missouri, with 138 students in the summer of 1967, the college moved to its 80-acre campus in August of 1979.

Currently Three Rivers has approximately 3,100 students enrolled in college transfer, career technical, developmental and continuing education courses.